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The main side effect is photosensitivity. You really need to be more careful in the sun.
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I want to share this. Many herbalists use ST JOHNS WORT OIL as sun protection.
Bubbles is right, it is said that St j's can cause photosensitivity, but there are so many practicing herbalsts that prove that wrong. I am not certain it is fact or if it is, it is in a small few.
St J's is used often for depression, of course as she said above.
Also though it is good for muscle relaxing. I used it in oil form during labor and delivery.
It helps restore damaged nerve tissue and also deadens nerve pain. It also stregthens urinary organs. good also for athletic injuries such as pulled muscles adn ligaments.
The botanical name is hypericum perforatum. Hyreicum translates "over an apparition"
The oil stains though so I am warning you if you buy oil and use externally. I ruined a few things.