Here's my only experience with it:
Dad has a fraternal twin sister. Mom has a fraternal twin brother. She also has fraternal twin sisters, the pg before Mom and Kevin (11 kids total, 9 pgs for Grandma). My bro and I - as well as all of my cousins - are singletons. So far, we've all also had only singletons. One of our children will likely have twins. (I think I have around 50 cousins, at last count.... gigantic extended family
)
Before my parents, my maternal side had twins appear in every other generation. My paternal side had twins every third generation. Based on that, we're all "betting"
on who of our children will have the twins when they're all old enough.
Short answer, I think it does run in families, but you have to go back at least to your own grandparents' families and look at all the generations to see if there's a pattern. Still no guarantee, but more like a 'preparation' for the what-if.